Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5510757 | Current Opinion in Structural Biology | 2017 | 8 Pages |
Abstract
Toll-like receptors (TLRs) activate the innate immune system in response to invading pathogens. Although nucleic acids are one of the principal TLR ligands, they are not inherently pathogen-specific and, thus, carry the risk of triggering autoimmunity. There are multiple unique regulatory mechanisms aimed at preventing accidental activation of nucleic acid-sensing TLRs. Recent structural studies revealed that different nucleic acid-sensing TLRs have specific modes of recognizing nucleic acids as ligands regulated by diverse regulation mechanism both at the receptor and ligand levels. This review summarizes structural knowledge on the ligand recognition and regulation mechanism by nucleic acid-sensing TLRs.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Toshiyuki Shimizu,