Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5510826 | Current Opinion in Structural Biology | 2017 | 6 Pages |
Abstract
Photo-controlled or 'optogenetic' effectors interfacing with endogenous protein machinery allow the roles of endogenous proteins to be probed. There are two main approaches being used to develop optogenetic effectors: (i) caging strategies using photo-controlled conformational changes, and (ii) protein relocalization strategies using photo-controlled protein-protein interactions. Numerous specific examples of these approaches have been reported and efforts to develop general methods for photo-control of endogenous proteins are a current focus. The development of improved screening and selection methods for photo-switchable proteins would advance the field.
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Authors
Katherine E Brechun, Katja M Arndt, G Andrew Woolley,