Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5511033 | DNA Repair | 2016 | 9 Pages |
Abstract
PARP responses in DNA strands-breaks context are functional in Drosophila model as demonstrated by PARP-I and PARP-II mRNA increases. However, no modification of the global PARylation profile is observed during strand-breaks generation, only changes at cellular levels are detectable. Taking together, these results demonstrate that PARylation process in Drosophila is tightly regulated in the context of strands-breaks repair and that PARP is essential during the maintenance of DNA integrity but dispensable in the DNA repair process.
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Authors
Layal Ishak, Amandine Moretton, Isabelle Garreau-Balandier, Mathilde Lefebvre, Serge Alziari, Philippe Lachaume, Frédéric Morel, Géraldine Farge, Patrick Vernet, Pascal Dubessay,