| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5511051 | DNA Repair | 2016 | 25 Pages |
Abstract
The clustered regularly interspaced short palindromic repeats (CRISPRs) and their associated proteins (Cas) belong to the crucial adaptive immune system, which exist in archaea and bacteria. Currently, CRISPR-Cas9 system has been modified and widely used to edit genome. In this review, we summarized the discovery, classification and mechanism of CRISPR-Cas system and further discussed the application of CRISPR-Cas9 in gene therapy, mainly in disease models.
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Authors
Lihong Guan, Yawei Han, Shaoyi Zhu, Juntang Lin,