Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5511259 | The International Journal of Biochemistry & Cell Biology | 2017 | 27 Pages |
Abstract
The folding of tRNA fragments (tRFs) into G-quadruplex structures and the implications of G-quadruplexes in translational inhibition have been studied mainly in mammalian systems. To increase our knowledge of these phenomena, we determined the influence of human and plant tRFs and model G-quadruplexes on translation in rabbit reticulocyte lysate and wheat germ extract. The efficiency of translational inhibition in the mammalian system was strongly associated with the type of G-quadruplex topology. In the plant system, the ability of a small RNA to adopt the G-quadruplex conformation was not sufficient to repress translation, indicating the importance of other structural determinants.
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Authors
Paulina Jackowiak, Anna Hojka-Osinska, Katarzyna Gasiorek, Michal Stelmaszczuk, Dorota Gudanis, Zofia Gdaniec, Marek Figlerowicz,