Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5511268 | The International Journal of Biochemistry & Cell Biology | 2017 | 56 Pages |
Abstract
While platelets are traditionally recognized to play a predominant role in hemostasis and thrombosis, increasing evidence verifies its involvement in malignancies. As a component of the tumor microenvironment, platelets influence carcinogenesis, tumor metastasis and chemotherapy efficiency. Platelets status is thus predictable as a hematological biomarker of cancer prognosis and a hot target for therapeutic intervention. On the other hand, the role of circulating tumor cells (CTCs) as an inducer of platelet activation and aggregation has been well acknowledged. The cross-talk between platelets and CTCs is reciprocal on that the CTCs activate platelets while platelets contribute to CTCs' survival and dissemination. This review covers some of the current issues related to the loop between platelets and tumor aggression, including the manners of tumor cells in “educating” platelets and biofunctional alterations of platelets upon tumor “education”. We also highlight the potential clinical applications on the interplay between tumors and platelets. Further studies with well-designed prospective multicenter trials may contribute to clinical “liquid biopsy” diagnosis by evaluating the global changes of platelets.
Keywords
PLCTCIPATMSgranulocyte colony-stimulation factorPDPNPlatelet lymphocyte ratioPMPsTGNPF4PLRGPCRsADPIL-1βOCsvWFRNA-seqqPCRCTCsCOX-2G protein-coupled receptorsNETsadenosine diphosphateILSInteractionlysosome-related organellesinterleukinsInterleukin-1βRNA sequencingCirculating tumor cellsCAMCirculating tumor cells (CTCs)open canalicular systemCyclooxygenase-2Trans-Golgi networkMass spectrometryTissue factorVon Willebrand factorG-CSFphospholipase CCell adhesion moleculeMicroRNAMiRNAPlatelet microparticlesquantitative polymerase chain reactionPARsPlateletsglycoproteinsprotease-activated receptors
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Authors
Qun Zhang, Hongda Liu, Qingqing Zhu, Ping Zhan, Suhua Zhu, Jianya Zhang, Tangfeng Lv, Yong Song,