The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a Î³H2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D

Article ID	Journal	Published Year	Pages	File Type
5511395	The International Journal of Biochemistry & Cell Biology	2017	58 Pages	PDF

Keywords

NAC 1-methyl-4-phenylpyridinium iodide Pepstatin A MDL28170 ataxia telangiectasia and Rad3-related protein A-T DNA-PK PSA ATR MMP DOX DSB ataxia telangiectasia mutated CGC MTT N-acetyl-cysteine ROS Hydrogen peroxide AIF staurosporine ATM Doxorubicin SH-SY5Y cells cerebellar granule cells apoptosis inducing factor lactate dehydrogenase LDH H2O2 DNA-dependent protein kinase Mitochondrial membrane potential Propidium iodide Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a Î³H2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D

Authors

Jakub Chwastek, Danuta Jantas, WÅadysÅaw LasoÅ,