| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5511472 | The International Journal of Biochemistry & Cell Biology | 2016 | 10 Pages |
Abstract
The present work describes not only the proteomic profile in RTT fibroblasts, but also identifies the modified proteins by 4-HNE and nitrotyrosine. Of note, for the first time, it appears that a dysregulation of NO pathway can be associated to RTT pathophysiology. In conclusion, the evidence of a wide range of proteins able to forms adducts with 4-HNE, Nitrotyrosine or with both confirms the possible alteration of several aspects of cellular functions that well correlates to the complex clinical features of RTT patients.
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Authors
Alessandra Pecorelli, Carlo Cervellati, Alessio Cortelazzo, Franco Cervellati, Claudia Sticozzi, Cristiana Mirasole, Roberto Guerranti, Alessandro Trentini, Lello Zolla, Vinno Savelli, Joussef Hayek, Giuseppe Valacchi,