| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5511654 | International Journal of Biological Macromolecules | 2017 | 11 Pages |
Abstract
A novel series of acridine-coumarin hybrids was synthesized and biologically evaluated for their potential inhibitory effect on both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The newly synthesized derivatives 9a-d have shown higher activity against human AChE (hAChE) compared with 7-MEOTA as the standard drug. Among them derivative 9b exhibited the most potent acetylcholinesterase inhibitory activity, with an IC50 value of 5.85 μM compared with 7-MEOTA (IC50 = 15 μM). Molecular modelling studies were performed to predict the binding modes of compounds 9b, 9c and 9f with hAChE/hBuChE.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Slavka Hamulakova, Ladislav Janovec, Ondrej Soukup, Daniel Jun, Kamil Kuca,