Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5511658 | International Journal of Biological Macromolecules | 2017 | 10 Pages |
Abstract
β-glucan is widely distributed in nature as water soluble and insoluble forms. Both forms of β-glucan are applied in several fields, especially for functional foods. Yeast β-glucan is a medically important insoluble particle. Solubilization of yeast β-glucan may be a valuable approach to increase functional foods and medicinal fields. We have applied a heat degradation method to solubilize yeast β-glucan and found that it was effectively solubilized by treatment with an aqueous suspension at 135 °C for several hours. The solubilized yeast β-glucan (hd-sBBG) exhibited antagonistic activity to the reactive oxygen production of macrophages and to the cytokine synthesis of macrophages. hd-sBBG strongly reacted with the anti-β-glucan antibody in human sera and with dectin-1, the innate immune receptor of β-glucan. From these findings, the heat degradation method is an important procedure for making immune modulating soluble yeast β-glucan.
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Authors
Yuina Ishimoto, Ken-ichi Ishibashi, Daisuke Yamanaka, Yoshiyuki Adachi, Ken Kanzaki, Kumiko Okita, Yoichiro Iwakura, Naohito Ohno,