Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5511707 | International Journal of Biological Macromolecules | 2017 | 52 Pages |
Abstract
The near future of drug delivery system would lie in the search of a versatile and innocuous material, based mostly on the natural resources. The tamarind seed xyloglucan (XG) is a natural neutral hemicellulose and a hydrophilic polysaccharide consisting of a main chain of glucan backbone with xylose and galactose side chains. XG is endowed with idiosyncratic mucoadhesive and in situ gelling properties which rated XG as an attractive, functional polymer for numerous drug delivery applications. In milieu of this, the present review is designed to underline the plausible potential of XG or XG-based systems in drug delivery. The feasibility of surface-tailoring, the flexibility of chemical-modification, and the possibility as ligand-conjugations grant XG an extraordinary consideration in the scientific territory. The authors are hopeful that the versatility of XG would meet the expectations of regulatory authorities and the XG-based products will serve the therapeutic needs of the community in the future, if sufficiently investigated and promising outcomes are obtained in human subjects.
Keywords
Tamarind seed xyloglucanSAXSPLATSPPAMTamarind kernel powderkDakiloDaltonGPCDPIMMAMitomycin CHCPTASGPRFourier transformed infra-red spectroscopy10-HydroxycamptothecinKetorolac tromethamineNLCsMMCNSAIDSMDRMCCDOXPCLnuclear magnetic resonancePolyacrylamideHET-CAMNPsEthyl acrylateDry powder inhalationDrug deliveryMucociliary clearanceNMRSurface-modificationNanostructured lipid carriersNon-steroidal anti-inflammatory drugsDoxorubicinXyloglucanZolmitriptanMontelukast sodiumTKPFTIRMethyl methacrylatenot specifiedMultidrug resistanceMucoadhesionNanoparticlesLidocaine hydrochlorideMolecular weightsmall angle X-ray ScatteringPoly(L-lactic acid)PMMATamarind seed polysaccharidepolymethyl methacrylatePolycaprolactoneIn situ gelGel permeation chromatography
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Authors
Abhijeet D. Kulkarni, Aditya A. Joshi, Chirag L. Patil, Prasad D. Amale, Harun M. Patel, Sanjay J. Surana, Veena S. Belgamwar, Kapil S. Chaudhari, Chandrakantsing V. Pardeshi,