Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5512122 | International Journal of Biological Macromolecules | 2016 | 53 Pages |
Abstract
Bone is a natural composite material consisting of an organic phase (collagen) and a mineral phase (calcium phosphate, especially hydroxyapatite). The strength of bone is attributed to the apatite, while the collagen fibrils are responsible for the toughness and visco-elasticity. The challenge in bone tissue engineering is to develop such biomimetic composite scaffolds, having a balance between biological and biomechanical properties. This review summarizes the current state of the field by outlining composite scaffolds made of gelatin/collagen in combination with bioactive ceramics for bone tissue engineering application.
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Authors
Shruthy Kuttappan, Dennis Mathew, Manitha B. Nair,