Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5512780 | The Journal of Nutritional Biochemistry | 2017 | 8 Pages |
Abstract
Fructose intake did not alter blood pressure, but did increase visceral fat deposition and fasting glucose as well as impair insulin and glucose tolerance. Fructose increased NE-induced vasoconstriction compared with CON, and this difference was abrogated by indomethacin perfusion as well as endothelium removal. ACh-induced relaxation was preserved, and the NO modulation tested after L-NAME perfusion was similar between groups. SNP-induced relaxation was not altered. Inducible NOS was increased; however, there were no changes in eNOS, Nox2 or COX-2 protein expression. Basal or stimulated superoxide anion production was not changed by fructose intake. In conclusion, high fructose intake increased NE-induced vasoconstriction through the endothelial prostanoids even in the presence of a preserved endothelium-mediated relaxation. No major changes in vessel structure were detected.
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Authors
Glauciene J. Sousa, Phablo Wendell C. Oliveira, Breno V. Nogueira, Antônio F. Junior, ThaÃs de Oliveira Faria, Eduardo Frizera Meira, José G. Mill, Nazaré S. Bissoli, Marcelo P. Baldo,