| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5512869 | The Journal of Nutritional Biochemistry | 2017 | 41 Pages |
Abstract
depicting the therapeutic potential of ILQ in experimental DN. Mitochondrial derangements occurred due to hyperglycaemia-induced inactivation of SIRT1-AMPK-PGC-1α signalling in experimental DN leads to neuronal dysfunction and nerve damage. ILQ exerts neuroprotection through SIRT1 induction and produces the similar protective effects as that observed with calorie restriction such as promotion of mitochondrial biogenesis, autophagy and oxidative stress resistance. (AMPK: AMP activated protein kinase, FOXO3a: Forkhead box O3, PGC-1α: peroxisome proliferator-activated receptor gamma coactivator 1 alpha, ROS: reactive oxygen species.)194
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Authors
Veera Ganesh Yerra, Anil Kumar Kalvala, Ashutosh Kumar,