| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5513140 | The Journal of Steroid Biochemistry and Molecular Biology | 2017 | 35 Pages |
Abstract
In conclusion, OCA treatment demonstrates cardiopulmonary protective effects, modulating lung vascular remodeling, reducing right ventricular hypertrophy and significantly improving exercise capacity. Thus, OCA can restore the balance between relaxant and contractile pathways in the lung, promoting cardiopulmonary protective actions.
Keywords
ACE2endothelin receptor type BFXRCDCABMP2BMPR1AET-1cox2cGMPETAETBECsfarnesoid X receptorAngiotensin-converting enzyme 2AChAcetylcholineChenodeoxycholic acidBile acidendothelin-1Endothelial cellsCyclooxygenase-2cyclic guanosine monophosphatebody weightbone morphogenetic protein 2endothelin receptor type A
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Authors
Linda Vignozzi, Annamaria Morelli, Ilaria Cellai, Sandra Filippi, Paolo Comeglio, Erica Sarchielli, Elena Maneschi, Gabriella Barbara Vannelli, Luciano Adorini, Mario Maggi,