| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5513163 | The Journal of Steroid Biochemistry and Molecular Biology | 2017 | 38 Pages |
Abstract
In conclusion, our results suggest an important protective effect of OCA against bleomycin-induced lung fibrosis by blunting critical mediators in the pathogenesis of IPF.
Keywords
C-X-C motif chemokine 12CD206Col3a1CD11cMMP2collagen, type I, alpha 1COL1A1αSMATGFβ1ETATTF-1RVHTIMP2OCACXCL12PDGFPDE5BMP2MMP7tissue inhibitor of metalloproteinases 2TGFβ2transforming growth factor, beta 1Et1SM22SNAI2MMP1ROCK2MMP9SNAI1FN1ATIIBMPR1AROCK1endothelin receptor type BTIMP1ETBIPFACE2IL-1βeNOScox2monocrotalineMCTMCP-1CTGFSHPRhoAHIF-1TGFβ3ATIPAOIL-6TNFαEGFBronchial Alveolar Lavage Fluidfarnesoid X receptorAngiotensinogenAlpha-smooth muscle actinNon-alcoholic steatohepatitisSprague-Dawleyobeticholic acidinflammationendothelin-1interleukin 1βinterleukin 6tissue inhibitor of metalloproteinases 1BALFright ventricleleft ventricleBleomycinTransgelintumor necrosis factor alphaEMTendothelial nitric oxide synthaseInterventricular septumCyclooxygenase-2small heterodimer partnerhypoxia-inducible factor 1-alphaepidermal growth factorRas homolog gene family member AVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Connective tissue growth factorthyroid transcription factor-1phosphodiesterase type 5Pulmonary fibrosisidiopathic pulmonary fibrosisMatrix metalloproteinase-7Matrix metalloproteinase-9Matrix metalloproteinase-1Matrix metalloproteinase-2Nash AGTRight ventricular hypertrophymonocyte chemoattractant protein-1bone morphogenetic protein 2endothelin receptor type A
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Authors
Paolo Comeglio, Sandra Filippi, Erica Sarchielli, Annamaria Morelli, Ilaria Cellai, Francesca Corcetto, Chiara Corno, Elena Maneschi, Alessandro Pini, Luciano Adorini, Gabriella Barbara Vannelli, Mario Maggi, Linda Vignozzi,