Hydrodynamics of a free-flowing leukocyte toward the endothelial wall

Using a recent validated mathematical model describing the coupled deformation-flow of an individual leukocyte in a microchannel, numerical simulations of an individual and of two leukocytes under flow were performed. The results showed that velocity plays an important role in the motion, deformation and attraction of the cells during an inflammatory response. In fact, for higher inlet velocities the cell movement along the endothelial wall is accelerated and the attraction forces break faster. These results highlight the role of the mechanical properties of the blood, namely the ones influenced by the velocity field, in the case of inflammation.