Allimacrosides A-E, new steroidal glycosides from Allium macrostemon Bunge

•Nine steroidal compounds including five new compounds were isolated from Allium macrostemon.•Their chemical structures were determined based on spectroscopic methods.•The isolateds were tested for cytotoxicity against four human tumor cell lines in vitro.

A new pregnane-type steroidal glycoside (1), two new spirostane-type steroidal glycosides (2, 3), and two new furostane-type steroidal glycosides (4, 5), named allimacrosides A-E, together with four known compounds (6-9) were isolated from a 80% MeOH extract of Allium macrostemon Bunge. The identification and structural elucidation of these compounds were based on their 1D- and 2D-NMR spectra, and HR-FAB-MS data analysis. The isolated compounds were tested for cytotoxicity against four human tumor cell lines in vitro using the sulforhodamine B bioassay.

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