Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5536213 | Tuberculosis | 2017 | 4 Pages |
Abstract
Molecular epidemiology analysis of tuberculosis transmission is based mostly on the application of MIRU-VNTR. In certain isolates a complete 24-loci genotype is not obtained and these incompletely genotyped isolates can not be used in the definition of clusters. In a population-based molecular epidemiology study performed in AlmerÃa, Southeast Spain, a context with a high proportion of immigrants, we found that an 88-bp deletion in isolates of Mycobacterium africanum Lineage 5 hampers MIRU-VNTR analysis. A more extensive analysis revealed that this deletion was shared by all the Lineage 5 isolates in certain countries of origin of immigrants, such as Equatorial Guinea, and is likely present in several other African countries and also in the USA. A procedure is proposed to enable epidemiological analysis of these isolates.
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Authors
EstefanÃa Abascal, Diana Maricela Herrera, Marta Herranz, Sheila Santantón, Miguel MartÃnez-Lirola, Griselda Tudó, Juliá Gonzalez, Emilio Bouza, Laura Pérez-Lago, DarÃo GarcÃa-de-Viedma,