Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5536216 | Tuberculosis | 2017 | 13 Pages |
Abstract
Mice of the genetically TB-susceptible strain I/St were infected with â¼100 CFU of Mycobacterium tuberculosis strain H37Rv, and after week 3 post-infection treated by inhalations of the NBD peptide selectively blocking NF-κB activation pathway. This therapy resulted in a pronounced attenuation of lung pathology and down-regulation of the expression of several genes encoding major inflammatory molecules, but did not diminish the level of mycobacterial multiplication in the lungs.
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Authors
Galena Shepelkova, Vladimir Evstifeev, Tatiana Kondratieva, Irina Bocharova, Mikhail Averbakh, Alexander Apt,