Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5536239 | Tuberculosis | 2017 | 14 Pages |
Abstract
Tuberculosis is a major public health concern, and diagnostic strategies applied to animal populations are scarce. As part of ongoing efforts to control tuberculosis dissemination at our animal facility, two non-human primates (NHP, Saimiri sciureus) presenting cutaneous lesions were examined for mycobacterial infection. Both animals tested positive for acid-fast bacilli and Mycobacterium tuberculosis using a molecular assay (IS6110 PCR). Animals were euthanized and several samples were tested for M. tuberculosis using the Xpert MTB/RIF assay. Many samples were positive for M. tuberculosis and rifampicin resistance, and some produced mycobacterial growth. Oral swabs from cage mates were then tested with Xpert MTB/RIF, and the majority tested positive for M. tuberculosis and rifampicin resistance, and produced growth in culture. To our knowledge, this is the first report of multidrug-resistant mycobacterial infection in NHP. Additionally, our data shows that the Xpert MTB/RIF assay can be useful as a screening tool for tuberculosis infection in NHP.
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Authors
Duanne Alves da Silva, Amanda M. Rêgo, Nicole V. Ferreira, Manoela A.S. de Andrade, Aline R. Campelo, Paulo César S. Caldas, Márcia Aparecida S. Pereira, Paulo Redner, Lucindo C. de Pina, Felipe C. Resende, Thalita A. Pissinatti, Claudia A.A. Lopes,