Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5536244 | Tuberculosis | 2017 | 7 Pages |
Abstract
PTB and LTBI groups exhibit higher BfrB-specific IFN-γ responses than HCs. Although BfrB is not as immunodominant as ESAT-6/CFP-10 during acute M.tb infection, comparable BfrB-specific cellular immune responses are observed in LTBI population with the potential to increase the sensitivity for LTBI screening. Moreover, strong BfrB-specific IFN-γ release in the healthy cohort is probably cautionary in identifying leaky LTBI from HCs. BfrB might thus be considered as an additional biomarker antigen for LTBI identification.
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Authors
Xinyu Yang, Jia-bao Wu, Ying Liu, Yanqing Xiong, Ping Ji, Shu-jun Wang, Yingying Chen, Guo-ping Zhao, Shui-hua Lu, Ying Wang,