Repopulation of the Atrophied Uterine in Diabetic Rats by Azadirachta excelsa Leaves Extract

The reduction of uterine strength is always a concern in diabetic women. Therefore the mechanism of Azadirachta excelsa for repairing the uterus structure in diabetic rats has been investigated. Twenty four Sprague dawley rats were divided into four groups which received different treatments for two weeks. Alloxan monohydrate at concentrations of 130 mg/kg of body weight was used to induce diabetes on rat model. On day 15 of treatment, after 8 hours of fast, all animals were scarified by decapitation. Blood were withdrawn for HbA1c and insulin analysis and uterine were harvested for histological study. Administration of plant extract was significantly reduced the precentage of HbA1c in diabetic rats by 6.58%. Otherwise, the concentration of plasma insulin in diabetic rats treated with plant extract was increased significantly. Microscopic observation was found that A.excelsa able to reduce atrophy and increase the proliferation of stromal cells in diabetic rats. These findings suggest that A.excelsa can potentially be developed as an alternative agent to normalize the distribution of stromal cells is an indicator towards improving the fertility in infertile and diabetic women.