| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5546536 | Acta Pharmaceutica Sinica B | 2017 | 10 Pages |
Abstract
A novel mucoadhesive and thermosensitive in situ hydrogel drug delivery system has been constructed based on amino-functionalized poloxamer 407 for vaginal administration. The system is easily administered and significantly prolongs intravaginal drug retention without obvious irreversible mucosal irritation.322
Keywords
ACNPorcine gastric mucinF127NFGDPHPGMpluronic F127ICRPoloxamer 407EMSDAPIPPOVFSDTTCDIPBSPDIDLSCMCnuclear magnetic resonance1,6-diphenyl-1,3,5-hexatrieneDIrH&EEDTAethylenediamine tetraacetic acidEndometriosisOctTemFourier transform infraredANOVAone-way analysis of varianceNMROptical coherence tomographydithiothreitolpolydispersity indexFTIRcritical micelle concentrationPhosphate buffered salineinstitute of cancer researchTransmission electron microscopyHematoxylin and EosinIn situ hydrogelDynamic Light ScatteringPoly(propylene oxide)poly(ethylene oxide)PEOCarbonyl diimidazoleAmino group
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Authors
Liqian Ci, Zhigang Huang, Yu Liu, Zhepeng Liu, Gang Wei, Weiyue Lu,