Article ID Journal Published Year Pages File Type
5546562 Acta Pharmaceutica Sinica B 2017 8 Pages PDF
Abstract
This review focuses on the vascular pharmacology of the natural compound thymoquinone. Thymoquinone causes both endothelium-independent dilatations of rat arteries, and endothelium-dependent augmentations of contraction in rat and pig arteries. These augmentations counterintuitively depend on biased activity of sGC, producing cyclic IMP rather than cyclic GMP.137
Keywords
Related Topics
Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Drug Discovery
Preview
Biased activity of soluble guanylyl cyclase: the Janus face of thymoquinone
Authors
, , ,