| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5546614 | Acta Pharmaceutica Sinica B | 2017 | 6 Pages |
Abstract
A pair of unusual new diphenyl glycerol ether enantiomers (â)-(S)-1 and (+)-(R)-1 and two new methyl benzamidobenzoates 2 and 3 were isolated from Chinese traditional herbal medicine “ban lan gen” (Isatis indigotica roots). The enantiomers were separated by HPLC on a chiral column. Compound 2 showed activities against replication of HSV-1 and Coxsackie virus B3 and against the LPS-induced NO production in mouse peritoneal macrophage. Compound 3 was active against HSV-1. These results, together with previous studies, demonstrate that the diverse chemical constituents with varied activities contribute to pharmacological efficacy that supports the traditional application of this herbal medicine.122
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Yufeng Liu, Minghua Chen, Qinglan Guo, Yuhuan Li, Jiandong Jiang, Jiangong Shi,