Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5546638 | Acta Pharmaceutica Sinica B | 2017 | 9 Pages |
Abstract
In this study, homology modeling and structure prediction tools such as RNA123 and SWISS-MODEL were used to generate the 40S ribosomal subunit from Plasmodium falciparum. This structure was modeled using the published crystal structure from Tetrahymena thermophila, a homologous eukaryote. In the absence of the Plasmodium falciparum 40S ribosomal crystal structure, the model accurately depicts a global topology, secondary and tertiary connections, and gives an overall root mean square deviation (RMSD) value of 3.9Â Ã
relative to the template׳s crystal structure. Structures generated from this study can be used in in silico screening experiments and lead to the determination of structures for targets/hit complexes.411
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Authors
Harrison Ndung'u Mwangi, Peter Wagacha, Peterson Mathenge, Fredrick Sijenyi, Francis Mulaa,