| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5547957 | European Journal of Pharmaceutical Sciences | 2016 | 5 Pages |
Abstract
Quantitative Systems Pharmacology (QSP) is an emerging science with increasing application to pharmaceutical research and development paradigms. Through case study we provide an overview of the benefits and challenges of applying QSP approaches to inform program decisions in the early stages of drug discovery and development. Specifically, we describe the use of a type 2 diabetes systems model to inform a No-Go decision prior to lead development for a potential GLP-1/GIP dual agonist program, enabling prioritization of exploratory programs with higher probability of clinical success.
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Keywords
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Theodore R. Rieger, Cynthia J. Musante,