Article ID Journal Published Year Pages File Type
5548087 Journal of Drug Delivery Science and Technology 2017 11 Pages PDF
Abstract

Rheumatoid arthritis (RA) is an autoimmune disorder distinct with series of complex change with unknown genesis. Constant effort has been made to treat RA through varied form of bioactives involving drugs, biologics, enzymes, genetic and hormones. Thus advancement in therapy involved introduction of targeted approaches and formulation of novel carters for efficient therapy. Current review is an attempt to contemplate RA in terms of pathogenesis, causative factors, targeted approaches, delivery of drugs through targeted ligands, novel carters as vesicular, particulate, self assembled, cellular and ceramic systems. Various polymeric components, drugs, biological molecules could be tailored directly or indirectly to target cells, bone site (hydoxyappatite), and macrophage cells to treat RA. The additional benefit of cellular carriers like erythrocytes and lymphocytes cells warrant likelihoods for delivery of peptides and recombinant proteins effectively.

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Related Topics
Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Drug Discovery
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