| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5548206 | Journal of Drug Delivery Science and Technology | 2017 | 8 Pages |
Thiol and amine difunctionalized porous silica (pSiO2-SH/NH2) nanoparticles (NPs) were prepared by condensation. The obtained pSiO2-SH/NH2 NPs present uniform spheres with size of 55Â nm. Folic acid (FA) as a tumor targeting agent was conjugated on the surface of pSiO2 NPs by amide linkage (pSiO2-SH/FA NPs), and captopril (Cap) as test drug was used to evaluate the releasing behavior. Results indicated that Cap is easily encapsulated into the pores of pSiO2-SH/FA NPs, which can further react with the inner thiols to form disulfide bonds. The Cap release from pSiO2-Cap/FA nanocarriers can be controlled by dithiothreitol (DTT) or reduced glutathione (GSH). The pSiO2-SH/FA nanocarriers showed low cytotoxicity and redox-responsive drug release.
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