Platinum pharmacokinetics in mice following inhalation of cisplatin dry powders with different release and lung retention properties

Article ID	Journal	Published Year	Pages	File Type
5550739	International Journal of Pharmaceutics	2017	14 Pages	PDF

Keywords

XRPD DPI ETAAS DPB TPGS tmax PSD USP EEM EED Carr’s index LLOQ terminal elimination rate constant SLM MCC Cmax l-leucine (PubChem CID: 6106)DSC FDA UDD UDM AUC Immediate release spray dried Controlled release peak concentration SCLC Mucociliary clearance Tristearin Particle size distribution LOD یا Limit of detection lower limit of quantification Intravenous Dae Solid lipid microparticles Food and Drug Administration NSCLC Small cell lung cancer Non-small cell lung cancer cisplatin Electrothermal Atomic Absorption Spectrometry pharmacokinetic Aerodynamic diameter limit of detection SEM area under the curve Scanning electron microscopy MPs terminal half-life body weight X-ray powder diffraction Dry powder for inhalation Dry powder inhaler Targeting efficiency Differential scanning calorimetry

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Platinum pharmacokinetics in mice following inhalation of cisplatin dry powders with different release and lung retention properties

Authors

Vincent Levet, Romain Merlos, Rémi RosiÃ¨re, Karim Amighi, Nathalie Wauthoz,