Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5550958 | International Journal of Pharmaceutics | 2016 | 8 Pages |
Abstract
Using a high-power CO2 laser to irradiate powder beds, it was possible to induce phase transformation to the amorphous state. Irradiation of a model drug, indometacin, resulted in formation of a glass. Varying the settings of the laser (power and raster speed) was shown to change the physicochemical properties of the glasses produced and all irradiated glasses were found to be more stable than a reference glass produced by melt-quenching. Irradiation of a powder blend of paracetamol and polyvinylpyrrolidone K30 was found to produce a solid amorphous dispersion. The results suggest that laser-irradiation might be a useful method for making amorphous pharmaceuticals.
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Related Topics
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Pharmacology, Toxicology and Pharmaceutical Science
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Authors
Varin Titapiwatanakun, Junlathip Tankul, Abdul W. Basit, Simon Gaisford,