| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5552246 | Biochemical Pharmacology | 2017 | 14 Pages |
Abstract
Antibiotics inhibit a wide range of essential processes in the bacterial cell, including replication, transcription, translation and cell wall synthesis. In many instances, these antibiotics exert their effects through association with non-coding RNAs. This review highlights many classical antibiotic targets (e.g. rRNAs and the ribosome), explores a number of emerging targets (e.g. tRNAs, RNase P, riboswitches and small RNAs), and discusses the future directions and challenges associated with non-coding RNAs as antibiotic targets.
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Authors
Savannah Colameco, Marie A. Elliot,