Gen-27, a newly synthesized flavonoid, inhibits glycolysis and induces cell apoptosis via suppression of hexokinase II in human breast cancer cells

Article ID	Journal	Published Year	Pages	File Type
5552323	Biochemical Pharmacology	2017	41 Pages	PDF

Keywords

DCFH/DA DAPI BCA Cyt C OXPHOS NAC PARP VDAC HKII PFK PVDF RTV FBS PGM1 PBS MMP LDHA 2′,7′-dichlorodihydrofluorescein diacetate 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide 4′,6-diamidino-2-phenylindole 6-Phosphofructo-2-kinase DMSO MTT N-acetylcysteine ROS bicinchoninic acid Tumor volume Apoptosis polyvinylidene difluoride Dimethylsulfoxide Breast cancer fetal bovine serum cytochrome c Phosphate buffered saline Oxidative phosphorylation phosphoglucomutase lactate dehydrogenase Mitochondria hexokinase II Mitochondrial membrane potential Propidium iodide poly (ADP-ribose) polymerase pyruvate kinase voltage-dependent anion channel Glycolysis Reactive oxygen species

Related Topics

Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology

Gen-27, a newly synthesized flavonoid, inhibits glycolysis and induces cell apoptosis via suppression of hexokinase II in human breast cancer cells

Authors

Lei Tao, Libing Wei, Yishi Liu, Yang Ding, Xiuting Liu, Xin Zhang, Xiaoping Wang, Yuyuan Yao, Jinrong Lu, Qing Wang, Rong Hu,