Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5554926 | Fitoterapia | 2017 | 4 Pages |
Abstract
Both the traditional Chinese medicinal fungus, Antrodia camphorata, and its secondary metabolite, 4,7-dimethoxy-5-methylbenzo[d][1,3]dioxole, have been reported to possess promising anticancer activity. In this work the natural product and analogues bearing more polar substituents were synthesised and assessed for antiproliferative activity in the NCI-60 screen. Although each compound inhibited the growth of some cell lines at 10 μM, none had sufficient activity to warrant further investigation.
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Authors
Sing Yee Yeung, Matthew J. Piggott,