| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5554934 | Fitoterapia | 2017 | 6 Pages |
Abstract
Seven new phloroglucinol derivatives, uraliones L-R (1-7), were isolated from the whole plant of Hypericum urialum. The structures of new compounds were unambiguously elucidated by comprehensive spectroscopic analysis, and the absolute configurations of the vic-diol groups were determined by Mo2(OAc)4-induced electronic circular dichroism experiments. Their capability to reversal the multidrug resistance in doxorubicin-induced resistant MCF-7/DOX sublines showed that compounds 1, 5, 6, 7 exerted a potential effect of doxorubicin susceptibility.
Graphical abstractDownload high-res image (260KB)Download full-size image
Keywords
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Pharmacology
Authors
Xiaoqing Li, Yun Li, Jianguang Luo, Zhongbo Zhou, Guimin Xue, Lingyi Kong,