Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5554950 | Fitoterapia | 2017 | 5 Pages |
Abstract
Pocahemiketals A and B (1 and 2), two novel hemiketal sesquiterpenoids with unprecedented skeletons, were isolated from the essential oil of the aerial parts of Pogostemon cablin. In addition to a bicyclo[3.2.1]-carbon core, 1 and 2 possessed a hemiketal α,β-unsaturated-γ-lactone moiety. Their structures were determined by extensive spectroscopic analysis, electronic circular dichroism calculation, and single-crystal X-ray diffraction. Compound 2 exhibited significant vasorelaxant activity against phenylephrine-induced contraction of a rat aorta ring with the EC50 value of 16.32 μM.
Graphical abstractDownload high-res image (253KB)Download full-size image
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Pharmacology
Authors
Huan Zhu, Qin-Mei Zhou, Cheng Peng, Ming-Hua Chen, Xiao-Nian Li, Da-Sheng Lin, Liang Xiong,