Article ID Journal Published Year Pages File Type
5554951 Fitoterapia 2017 7 Pages PDF
Abstract

Nine new phenalenone derivatives (1-9), along with two known analogues (10 − 11) have been isolated from the solid cultures of an endophytic fungus Aspergillus sp. which was obtained from Pinellia ternate. Their structures were established through interpretations of spectroscopic evidence, and some of their absolute configurations were determined by electronic circular dichroism (ECD) and Mo2(OCOCH3)4 induced ECD. All of the phenalenones are unusual acyclic diterpenoid adducts, which are diversely oxidized and partly epoxidized to form different heterocycles. In addition, compound 10 exhibited significant antimicrobial activity against Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis with MIC50 values of 1.87, 2.77, and 4.80 μg/mL, respectively.

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Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology
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