| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5554960 | Fitoterapia | 2017 | 5 Pages |
Abstract
Phytochemical investigation on the 70% EtOH extract of the leaves and branches of Gelsemium elegans resulted into the isolation of five new gelsedine-type oxindole alkaloids, gelseleganins A-E (1-5). The structures of the isolated compounds were established based on 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated alkaloids were tested in vitro for cytotoxic potential against seven tumor cell lines. As a result, alkaloids 3 exhibited significant cytotoxic activities against all the tested tumor cell lines with IC50 values < 10 μM.
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Authors
Lei Wang, Jin-Feng Wang, Xia Mao, Li Jiao, Xiao-Jun Wang,