Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5554994 | Fitoterapia | 2017 | 4 Pages |
Abstract
Five new isocoumarin derivatives, pestalactone A-C (1-3) and pestapyrone D-E (4-5), together with two known compounds (6-7) were isolated from the solid cultures of the endophytic fungus Pestalotiopsis sp. obtained from Photinia frasery. Their structures were mainly determined by extensive spectroscopic analysis, Mo2(OCOCH3)4-induced electronic circular dichroism (ECD), and ECD calculation. Compounds 1 and 2 were rare isocoumarin derivatives and derived from distinctive polyketide pathways. Compound 3 exhibited potent antifungal activity against Candida glabrata (ATCC 90030) with an MIC50 value of 3.49 ± 0.21 μg/mL.
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Pharmacology, Toxicology and Pharmaceutical Science
Pharmacology
Authors
Ren-Yu Song, Xiao-Bing Wang, Guo-Ping Yin, Rui-Huan Liu, Ling-Yi Kong, Ming-Hua Yang,