| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5555011 | Fitoterapia | 2017 | 7 Pages |
Abstract
Six new compounds, wikstronin A (1), wikstronin B (2), wikstresinol (3), acetylwikstresinol (4), bis-5â²,5â²-(+)-matairesinol (5), bis-5,5â²-(+)-matairesinol (6), together with 20 known compounds (7-26) were isolated from the CH2Cl2 extract of roots of Wikstroemia indica. Structures of compounds 1-6 were determined by extensive NMR and CD spectroscopic analysis. In vitro preferential cytotoxicity of all the isolates was evaluated against a PANC-1 human pancreatic cell line. Compounds 8 and 12 displayed mild preferential cytotoxicity in the nutrient-deprived medium (NDM) and without causing toxicity in normal nutrient-rich conditions.
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Authors
Hang Chang, Yuwei Wang, Xue Gao, Zehai Song, Suresh Awale, Na Han, Zhihui Liu, Jun Yin,