| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5555014 | Fitoterapia | 2017 | 5 Pages |
Abstract
Five new aspidofractinine-type alkaloids, kopsiahainins A-E (1-5), were isolated from a 80% EtOH extract of the leaves and stems of Kopsia hainanensis. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D-NMR, IR, UV, and HR-ESI-MS. Alkaloids 3 and 4 exhibited some cytotoxic activity against all of six tested tumor cell lines (BGC-823, HepG2, MCF-7, SGC-7901, SK-MEL-2, and SK-OV-3) with IC50 values of 7.3-9.5 μM and 9.2-10.6 μM, respectively.
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Pharmacology
Authors
Ying Wang, Lei Hang, Li Jiao, Hui Liu, Fei Li,