| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5555026 | Fitoterapia | 2017 | 6 Pages |
Abstract
A biological screening of sixteen lichen extracts on human HT-29 colorectal cancer cells, led to the selection of Pleurosticta acetabulum, a lichen widely present in tree barks in Europe. Bioguided purification of the acetonic extract resulted in the isolation of cytochalasin E, a common fungal metabolite. This compound is responsible for the anti-proliferative activity of the extract. Its presence in lichens is reported here for the first time. LC-MS quantitation of cytochalasin E in different samples of P. acetabulum demonstrated quantitative variations of cytochalasin E production in the lichen and especially high concentrations in apothecia.
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Authors
Sylvie Delebassée, Lengo Mambu, Emilie Pinault, Yves Champavier, Bertrand Liagre, Marion Millot,