Seven new lignan glycosides from the branches of Alangium kurzii Craib var. laxifolium

Seven new lignan glycosides (1-3, 8-10, and 14) and 17 known compounds were isolated from the branches of Alangium kurzii Craib var. laxifolium. Their structures were established by spectroscopic analysis and circular dichroism (CD) and X-ray analysis. The isolated compounds were evaluated for their antibacterial activities against Staphylococcus aureus CI1011, Streptococcus suis CI1608, Salmonella gallinarum CI0912, Enterococcus faecalis CI1304, Aeromonas hydrophila CI1008, Escherichia coli CI151012, Vibrio parahaemolyticus CI150506, Klebsiella pneumoniae CI131216, Pseudomonas aeruginosa CI1011, Staphylococcus epidermidis CI1110, and Streptococcus agalactiae CI1302. Their minimum inhibitory concentrations (MICs) were determined by serial dilution in 96-well culture plates.

Graphical abstractSeven new lignan glycosides (1-3, 8, 9-10, and 14) and 17 known compounds were isolated from the branches of Alangium kurzii Craib var. laxifolium. Structures were elucidated by spectroscopic data, X-ray crystallography and CD data. All of isolated compounds against ten selected strains were evaluated.Download high-res image (197KB)Download full-size image