Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5555095 | Fitoterapia | 2016 | 7 Pages |
Abstract
Four new polyisoprenylated benzoylphloroglucinol derivatives, hyperscabrones J-M (1-4), were isolated from the air-dried aerial parts of Hypericum scabrum. Their structures were elucidated by spectroscopic methods and were subsequently confirmed by comparing with data of known compounds. The absolute configuration of the bicyclo[3.3.1]nonane-2,4,9-trione core was defined by the experimental and calculated electronic circular dichroism (ECD) spectra. The evaluation of their hepatoprotective activities against paracetamol-induced HepG2 cell damage showed that compounds 2 and 4 exhibited significant hepatoprotection at 10 μM.
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Pharmacology, Toxicology and Pharmaceutical Science
Pharmacology
Authors
Wan Gao, Jia-Wen Hu, Fang Xu, Can-Jing Wei, Meng-Jiao Shi, Jun Zhao, Jia-Jia Wang, Bo Zhen, Teng-Fei Ji, Jian-Guo Xing, Zheng-Yi Gu, Fang Xu,