Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5555124 | Fitoterapia | 2017 | 7 Pages |
Abstract
Eight new γ-lactam alkaloids, hemerominors A-H (1-8), including two pair of epimers (1-4), together with six known compounds (9-14) were isolated from the roots of Hemerocallis minor Mill. The structures of 1-8 were established on the basis of extensive NMR studies and HR-MS measurements as well as comparison with literature data. The absolute configurations of 1-8 were determined by CD spectral analysis and modified Mosher's method. All of compounds were evaluated for their inhibitory effects against LPS-induced NO production in RAW264.7 macrophages. Among them, compound 13 exhibited moderate inhibitory activity against NO production and with IC50 value of 18.0 μM.
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Pharmacology, Toxicology and Pharmaceutical Science
Pharmacology
Authors
Yu Zhang, Xin-cai Zhao, Yang-guo Xie, Chao Fan, Ying-ying Huang, Shi-kai Yan, Yan Zhang, Hui-zi Jin, Wei-dong Zhang,