Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5555157 | Fitoterapia | 2017 | 5 Pages |
Abstract
Four new flavonoids, artoheteroids A-D (1-4), together with six known ones (5-10), were isolated from the roots of Artocarpus heterophyllus. Their structures were elucidated by spectroscopic methods, including 1D and 2D NMR, UV, IR, CD, and HR-ESI-MS. All isolated compounds were screened for their inhibitory abilities against cathepsin K (CatK). Among them, compounds 1-2, 4-6, and 10 were found to have suppression capabilities against CatK with IC50 values ranging from 1.4 to 93.9 μM.
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Authors
Wen-Jun Yuan, Jin-Bin Yuan, Jia-Bing Peng, Yuan-Qing Ding, Ji-Xiao Zhu, Gang Ren,