| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5556616 | Journal of Pharmacological and Toxicological Methods | 2016 | 7 Pages |
Abstract
This new temperature-sensitive model of hERG gating represents an attempt to improve the predictivity of safety pharmacology testing by enabling the translation of room temperature hERG assay data to more physiological conditions. With further development, this model can be incorporated into the CiPA paradigm and also be used as a tool for developing insights into the thermodynamics of hERG channel gating mechanisms and the temperature-dependence of hERG channel block by drugs.
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Authors
Zhihua Li, Sara Dutta, Jiansong Sheng, Phu N. Tran, Wendy Wu, Thomas Colatsky,