Sulforaphane inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting mTOR/p70S6kinase signaling independent of Nrf2 activation

Article ID	Journal	Published Year	Pages	File Type
5557444	Pharmacological Research	2017	64 Pages	PDF

Keywords

mTOR PDGF CREB 4E-BP1 Heme oxygenase-1 GSK3β FKBP12 mTORC1 p70S6K Regulatory associated protein of mTOR PFA PRB SM α-actin SFN EVG MEK1 HO-1 FK506-binding protein 12 DAB PBS mTOR complex 2 RHEB Kelch-like ECH associated protein 1 Eukaryotic translation initiation factor 4E-binding protein 1 IEL mTORC2 EEL Nrf2 Sulforaphane (PubChem CID: 5350)keap1 DMSO ERK1/2 H&E extracellular signal-regulated kinase1/2 mTOR complex 1 p70S6 kinase PI 3-kinase Room temperature Dimethyl sulfoxide (PubChem CID: 679)diaminobenzidine Dimethyl sulfoxide Ras homolog enriched in brain Raptor Rictor Sulforaphane Smooth muscle α-actin antioxidant response element platelet-derived growth factor nuclear factor erythroid 2-related factor 2 phosphoinositide 3-kinase external elastic lamina internal elastic lamina Phosphate-buffered saline mammalian target of rapamycin ARE haematoxylin and eosin rapamycin-insensitive companion of mTOR Elastic Van Gieson paraformaldehyde cAMP-response element-binding protein

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Sulforaphane inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting mTOR/p70S6kinase signaling independent of Nrf2 activation

Authors

Noha M. Shawky, Lakshman Segar,