Article ID Journal Published Year Pages File Type
5557655 Pharmacology & Therapeutics 2017 9 Pages PDF
Abstract

Antimicrobial peptides (AMPs) have evolved through billions of years as part of our innate immune system. These agents are produced by various cells throughout the human body and play important roles in our ability to respond to infections. In this review, we outline evidence linking AMP expression with a range of inflammatory and autoimmune human diseases. Finally, we highlight the promise of endogenous AMP induction for the treatment of disease (i.e., host-directed therapy) and briefly mention the different peptide drugs that are currently undergoing clinical trials.

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Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology
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